The Italian footballers are preparing for the Euro 2016 tournament in Spain on Saturday and on Monday they will be playing in the same stadium.
Mario Balotelli, Andrea Pirlo and Francesco Totti will be the key players for Italy against the Spanish side on Friday night, with the other two forwards Mario Balotella and Francesc Totti both being included in the squad that is to take on Spain in the last-16 of the tournament.
They will play the Spanish team at 2pm on Saturday night at the Stadio San Siro, a stadium that is currently under construction for the tournament but has already been converted into a home for the team.
Italy have been hoping to win the competition after winning it in 2015, beating Spain in a tight 3-2 victory.
They lost in the quarter-finals to France but they are still favourites to go through, while the reigning champions, Spain, have been struggling to find a winner.